Journal of Bionic Engineering ›› 2020, Vol. 17 ›› Issue (1): 76-91.doi: 10.1007/s42235-020-0006-7
A Study on the Biocompatibility of MgO Coating Prepared by Anodic Oxidation Method on Magnesium Metal
Yangmei Chen1,2,3†, Xugang Lu1,2,3†, Fenghua Zhao1,2,3, Yi Hu1,2,3, Shibing Xiong1,2,3,Yuqiang Guo1,2,3, Ping Huang5, Bangcheng Yang1,2,3,4*
- 1. Engineering Research Center in Biomaterials, Sichuan University, Chengdu 610064, China
2. National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China
3. Sichuan Guojia Biomaterials Co., Ltd, Chengdu 610064, China
4. Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing Normal University, Nanjing 210046, China
5. Panzhihua International Research Institute of Vanadium and Titanium, Panzhihua University, Panzhihua 617000, China
A Study on the Biocompatibility of MgO Coating Prepared by Anodic Oxidation Method on Magnesium Metal
Yangmei Chen1,2,3†, Xugang Lu1,2,3†, Fenghua Zhao1,2,3, Yi Hu1,2,3, Shibing Xiong1,2,3,Yuqiang Guo1,2,3, Ping Huang5, Bangcheng Yang1,2,3,4*
- 1. Engineering Research Center in Biomaterials, Sichuan University, Chengdu 610064, China
2. National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China
3. Sichuan Guojia Biomaterials Co., Ltd, Chengdu 610064, China
4. Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing Normal University, Nanjing 210046, China
5. Panzhihua International Research Institute of Vanadium and Titanium, Panzhihua University, Panzhihua 617000, China
摘要： Magnesium (Mg), is widely used for the bone repair in oral and orthopedic application due to excellent bioactivity, degradation and
biocompatibility. However, the range of application is greatly limited because of the rapid degradation of Mg metal in the body. Surface
modification is an effective method to enhance the corrosion resistance and reduce the degradation rate of Mg metal. In the present study,
pure Mg metal (P-Mg) was subjected to alkali-heat treatment (AT-Mg) or anodic oxidation-heat treatment (AO-HT-Mg). Both AT-Mg and
AO-HT-Mg had a layer of MgO on their surfaces after treatment. Then the effects of MgO coating on corrosion resistance, bioactivity,
Mesenchymal Stem Cells’ (MSCs) proliferation, adhesion and osteogenic differentiation, and the bone repair capability of Mg metal were
investigated. We found both AT-Mg and AO-HT-Mg had stronger corrosion resistance than P-Mg. MSCs on both AT-Mg and AO-HT-Mg
had higher expression of proteins and genes of ALP, OCN, Col-I and Runx2 than those on P-Mg. They also showed better bone repair
property than P-Mg in vivo. In general, MgO layer formed by anodic oxidation-heat treatment had better resistance and biocompatibility
than that produced by alkali-heat treatment. This study indicated the MgO coating not only improved the corrosion resistance of Mg metal,
but also promoted the osteogenic differentiation of MSCs and bone regeneration.